Cultivars in natural settings
Many cultivars are "naturalized" in gardening, planted out and largely left to their own devices. With pollination and regrowth from seed, true natural processes, the distinct cultivars will over time disappear. The cultivar's genetic material however may become part of the gene pool of a population, where it will be swamped. This is why many trees are culled when a "back to nature" regime is in place.
Cultivars that have originated as hybrids of different species are exotic, as is a plant from a different continent. They are in itself a threat to the true type of a species.
Legal point
With plants produced by genetic engineering becoming more and more widely introduced, it is important to note that the companies of these plants claim patent on their product. Therefore the notion that a plant that occurs from seed is natural is not appropriate any more.
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