Golgi apparatus
- "Golgi Apparatus" is also a song by Phish.
In
cell biology, the
Golgi apparatus,
Golgi complex, or
dictyosome is an
organelle found in nearly all
eukaryotic cells. The name comes from
Camillo Golgi, who identified it. Its primary function is to process
ribosomal proteins, and sort them within
vesicles. Thus, it functions as a sort of central delivery system for the cell.
Most of the transport vesicles that leave the
endoplasmic reticulum (ER), specifically
rough ER, are transported to the Golgi apparatus, where they are modified, sorted and shipped towards their final destination. The Golgi apparatus is present in most
eukaryotic cellss, but tends to be more prominent where there are a lot of substances, such as
enzymes, being secreted.
Structure
The structure and internal function of the Golgi apparatus is quite complex and subject of scientific dispute. The Golgi apparatus consists, like the ER, of membranous structures. It is made up of a stack of flatterned cisternae and similar vesicles. The cis face is the side facing the ER, the medial region is in the middle while the trans face is directed towards the plasma membrane (Fig. 1). The cis and trans faces have different membranous compositions.\nProcess
{|\n|
\n|Figure 1: Image of nucleus, endoplasmic reticulum and Golgi apparatus.
\n\n#Nucleus.\n#Nuclear pore.\n#Rough endoplasmic reticulum (RER).\n#Smooth endoplasmic reticulum (SER).\n#Ribosome on the rough ER.\n#Proteins that are transported.\n#Transport vesicle.\n#Golgi apparatus\n#Cis face of the Golgi apparatus.\n#Trans face of the Golgi apparatus.\n#Cisternae of the Golgi apparatus.\n#Secretory vesicle.\n#Plasma membrane.\n#Expelled proteins.\n#Cytoplasm.\n#Extracellular space.\n|}
The transport vesicles from the ER fuse with the cis face of the Golgi apparatus (to the cisternae) and empty their protein content into the Golgi lumen. The proteins are then transported through the medial region towards the trans face and are modified on their way.
The transport mechanism itself is not yet clear; it could happen by cisternae progression (the movement of the apparatus itself, building new cisternae at the cis face and destroying them at the trans face) or by budding (small vesicles transport the proteins from one cisterna to the next, while the cisternae remain unchanged).
Once the proteins reach the trans face, they are embedded into coated transport vesicles and brought to their final destinations.
An example is the formation of glycoproteins (used in cell membranes). Vesicles from the ER have proteins. In the Golgi Apparatus carbohydrates are attached to them creating glycoproteins. After they have been secreted in to the cell the vesicles fuse to the cell membrane and release their contents.
Other functions
As well as protein modification, Golgi apparatus is involved in the transport of lipids around the cell as well creating lysosomes - organelles involved in digestion.
See also : biology
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Category:OrganellesCategory:Eponymous anatomical structures
